On the ground, far away, Dr. Alexander Kellis was weeping without shame over the destruction of his lab, and making dire predictions about what could happen now that his creation was loose in the world. Like Dr. Frankenstein before him, he had created with only the best of intentions and now found himself facing an uncertain future. His lover tried to soothe him and was rebuffed by a grief too vast and raw to be put into words.
Alpha-RC007—colloquially known as “the Kellis cure”—did not grieve, or love, or worry about the future. Alpha-RC007 only drifted.
The capsid structure of Alpha-RC007 was superficially identical to the structure of the common rhinovirus, being composed of viral proteins locking together to form an icosahedron. The binding proteins, however, were more closely related to the coronavirus ancestors of the hybrid, creating a series of keys against which no natural immune system could lock itself. The five viral proteins forming the capsid structure were equally mismatched: two from one family, two from the other, and the fifth…
The fifth was purely a credit to the man who constructed it, and had nothing of Nature’s handiwork in its construction. It was a tiny protein, smaller even than the diminutive VP4, which made the rhinovirus so infectious, and formed a ring of Velcro-like hooks around the outside of the icosahedron. That little hook was the key to Alpha-RC007’s universal infection rate. By latching on and refusing to be dislodged, the virus could take as much time as it needed to find a way to properly colonize its host. Once inside, the other specially tailored traits would have their opportunity to shine. All the man-made protein had to do was buy the time to make it past the walls.
The wind currents eddied around the tiny viral particles, allowing them to drop somewhat lower in the stratosphere. Here, a flock of geese was taking advantage of the air currents at the very edge of the atmospheric layer, their honks sounding through the thin air like car alarms. One, banking to adjust her course, raised a wing just a few inches higher, tilting herself hard to the right and letting her feathers brush through the upper currents.
As her feathers swept through the air, they collected dust and pollen—and a few opportunistically drifting particles of Alpha-RC007. The hooks on the outside of the virus promptly latched on to the goose’s wing, not aware, only reacting to the change in their environment. This was not a suitable host, and so the bulk of the virus remained inert, waiting, letting itself be carried along by its unwitting escort back down to the planet’s surface.
Honking loudly, the geese flew on. In the air currents above them, the rest of the viral particles freed from Dr. Alexander Kellis’s lab drifted, waiting for their own escorts to come along, scoop them up, and allow them to freely roam the waiting Earth. There is nothing so patient, in this world or any other, as a virus searching for a host.
* * *
We’re looking at clear skies here in the Midwest, with temperatures spiking to a new high for this summer. So grab your sunscreen and plan to spend another lazy weekend staying out of the sun! Pollen counts are projected to be low…
June 13, 2014: Denver, Colorado
Suzanne Amberlee had been waiting to box up her daughter’s room almost since the day Amanda was first diagnosed with leukemia. Her therapist said it was a “coping mechanism” for her, and that it was completely healthy for her to spend hours thinking about boxes and storage and what to do with things too precious to be given to Goodwill. As the parent of a sick child, she’d been all too willing to believe that, grasping at any comfort that her frightened mind could offer her. She had made her lists long ago. These were the things she would keep; these were the things she would send to family members; these were the things she would give to Amanda’s friends. Simple lines, drawn in ink on the ledger of her heart.
That was thought. The reality of standing in her little girl’s bedroom and imagining it empty, stripped of all the things that made it Amanda’s, was almost more than she could bear. After weeks of struggling with herself, she had finally been able to close her hand on the doorknob and open the bedroom door. She still wasn’t able to force herself across the threshold.
This room contained all Amanda’s things—all the things she’d ever have the opportunity to own. The stuffed toys she had steadfastly refused to admit to outgrowing, saying they had been her only friends when she was sick and she wouldn’t abandon them now. Her bookshelves, cluttered with knickknacks and soccer trophies as much as books. Her framed poster showing the structure of Marburg EX19, given to her by Dr. Wells after the first clinical trials began showing positive results. Suzanne could picture that day when she closed her eyes. Amanda, looking so weak and pale, and Dr. Wells, their savior, smiling like the sun.
“This little fellow is your best friend now, Amanda.” That was what he’d said on that beautiful afternoon where having a future suddenly seemed possible again. “Take good care of it and it will take good care of you.”
Rage swept over Suzanne in a sudden hot wave. She opened her eyes, glaring across the room at the photographic disease. Where was it when her little girl was dying? Marburg EX19 was supposed to save her baby’s life, and in the end, it had let her down; it had let Amanda die. What was the good of all this—the pain, the endless hours spent in hospital beds, the promises they never got to keep—if the damn disease couldn’t save Amanda’s life?
Never mind that Amanda died in a car crash. Never mind that cancer had nothing to do with it. Marburg EX19 was supposed to save her, and it had failed.
“I hate you,” Suzanne whispered, and turned away. She couldn’t deal with the bedroom; not today, maybe not ever. Maybe she would just sell the house, leave Amanda’s things where they were, and let them be dealt with by the new owners. They could filter through the spindrift of Amanda’s life without seeing her face, without hearing her voice talking about college plans and careers. They could put things in boxes without breaking their hearts.
If there was anything more terrible for a parent than burying a child, Suzanne Amberlee couldn’t imagine what it would be. Her internal battle over for another day—over, and lost—she turned away, heading down the stairs. Maybe tomorrow she could empty out that room. Maybe tomorrow she could start boxing things away. Maybe tomorrow she could start the process of letting Amanda go.
Maybe tomorrow. But probably not.
Suzanne Amberlee walked away, unaware of the small viral colony living in her own body, nested deep in the tissue of her lungs. Content in its accidental home, Marburg EX19 slept, waiting for the trigger that would startle it into wakefulness. It was patient; it had all the time in the world.
* * *
Amanda Amberlee is survived by her mother, Suzanne Amberlee. In lieu of flowers, the family asks that donations be sent to the Colorado Cancer Research Center…
June 15, 2014: Reston, Virginia
“Alex?”
The lights were off in the main lab, leaving it in claustrophobic darkness. Most of the staff had long since gone home for the night. That made sense; it had been past eleven when John Kellis pulled into the parking lot, and the only car parked in front of the building was his husband’s familiar bottle-green Ford. He hadn’t bothered to call before coming over. Maybe some men strayed to bars or strip clubs. Not Alex. When Alex went running to his other lover, he was always running to the lab.
John paused before pushing open the door leading into the inner office. The last thing he wanted to do was upset Alex further when he was already so delicate. “Sweetheart? Are you in here?”
There was still no answer. John’s heart started beating a little faster, spurred on by fear. The pressure had been immense since the break-in. Years of research gone; millions of dollars in private funding lost; and perhaps worst of all, Alex’s sense of certainty that the world would somehow start playing fair, shattered. John wasn’t sure that Alex could recover from that, and if Alex couldn’t recover, then John didn’t think he could recover, either.
This lab had been their life for so long. Vacations had been planned around ongoing research; even the question of whether or not to have a baby had been put off, again and again, by the demands of Alex’s work. They had both believed it was worth it for so long. Was one act of ecoterrorism going to change all that?
John was suddenly very afraid that it was.
“I’m back here, John,” said Alex’s voice. It was soft, dull…dead. Heart still hammering, John turned his walk into a half jog, rounding the corner to find himself looking at the glass window onto the former hot room. Alex was standing in front of it, just like he had so many times before, but his shoulders were stooped. He looked defeated.
“Alex, you have to stop doing this to yourself.” John’s heartbeat slowed as he saw that his husband was unharmed. He walked the rest of the distance between them, stopping behind Alex and sliding his arms around the other man’s shoulders. “Come on. Come home with me.”
“I can’t.” Alex indicated the window. “Look.”
The hot room had been resealed after the break-in; maybe they couldn’t stop their home-brewed pathogens from getting out, but they could stop anything new from getting in. The rhesus monkeys and guinea pigs were back in their cages. Some were eating, some were sleeping; others were just going about their business, oblivious to the humans watching over them.
“I don’t understand.” John squinted, frowning at the glass. “What am I supposed to be seeing? They all look perfectly normal.”
“I’ve bathed them in every cold sample I could find, along with half a dozen flus and an airborne form of syphilis. One of the guinea pigs died, but the necropsy didn’t show any sign that it was either an infection or the cure that killed it. Sometimes guinea pigs just die.”
“I’m sorry. I don’t understand the problem. What’s wrong with your lab animals being healthy?”
Alexander Kellis pulled away from his husband, expression anguished as he turned to face him. “I can’t tell which ones have caught the cure and which haven’t. It’s undetectable in a living subject. After the break-in, we’re probably infected, too. And I don’t know what it will do in a human host. We weren’t ready.” He started to cry, looking very young and very old at the same time. “I may have just killed us all.”